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Using two separate drugs to lose weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you should err to the side of caution and let the FDA do its job and demand some investigation be done so that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on their medications. Researchers found out that participants investing in this drug to get a year, dropped excess weight within four weeks and have kept the body weight off through the 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, that might make them far better and safer. Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that since right now there are no long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure and heartbeat, and shouldn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. "This may be the first drug I'm conscious of that targets the two appetite and reward centres in the brain," he explained.